Spain included Barcelona's Ansu Fati but left out Liverpool midfielder Thiago Alcantara and Manchester United goalkeeper David de Gea from their 26-man World Cup squad on Friday.
Fati, now 20, made his international debut in 2020 at 17 and in his second game became the youngest player to score for Spain, breaking a record held since 1925 by Juan Errazquien.
But the forward is fighting his way back from four surgeries to repair an injury to his left knee, suffered in November 2020.
Spain have been drawn in Group E with Costa Rica, Germany and Japan.
Luis Enrique declined to comment on the players who were left out, but the absence of veterans like De Gea, Thiago and Barcelona defender Marcos Alonso points to the manager's preference to go all-in with Spain's new generation of talent.
De Gea has fallen out of favour with Luis Enrique who said in March he "wanted to test other goalkeepers" and Thiago saw his role diminish with the rise of Barca teenagers Pedri, 19, and 18-year-old Gavi.
SEE SQUAD BELOW
Goalkeepers: Unai Simon (Athletic Bilbao), Robert Sanchez (Brighton & Hove Albion), David Raya (Brentford).
Defenders: Cesar Azpilicueta (Chelsea), Dani Carvajal (Real Madrid), Eric Garcia (Barcelona), Hugo Guillamon (Valencia), Pau Torres (Villarreal), Aymeric Laporte (Manchester City), Jordi Alba (Barcelona), Jose Gaya (Valencia).
Midfielders: Sergio Busquets (Barcelona), Rodri Hernandez (Manchester City), Gavi (Barcelona), Carlos Soler (Paris St Germain), Marcos Llorente (Atletico Madrid), Pedri Gonzalez (Barcelona), Koke Resurreccion (Atletico Madrid).
Forwards: Ferran Torres (Barcelona), Nico Williams (Athletic Bilbao), Yeremi Pino (Villarreal), Alvaro Morata (Atletico Madrid), Marco Asensio (Real Madrid), Pablo Sarabia (Paris St Germain), Dani Olmo (RB Leipzig), Ansu Fati (Barcelona)